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Compared to silica, kieselguhr has a small surface of low activity → application in partition chromatography; impregnated with various substances (paraffin, silicone oil, undecane) it can be used for reversed phase chromatography

The following grades of kieselguhr are manufactured by Johns-Manville. They are narrowly classified with homogeneous particle size distributions and high purity

For columns packed with kieselguhr please see CHROMABOND XTR for liquid-liquid extraction